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Comment
. 2013 Apr 1;591(7):1585-6; discussion 1587.
doi: 10.1113/jphysiol.2012.247726.

CrossTalk Opposing View: TARPs Modulate AMPA Receptor Conformations Before the Gating Transitions

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CrossTalk Opposing View: TARPs Modulate AMPA Receptor Conformations Before the Gating Transitions

David M MacLean. J Physiol. .
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Figure 1
Figure 1. Kinetic scheme of AMPA receptor gating
Agonists bind to state ‘R’ leading to the formation of an agonist-bound cleft open state ‘AR’. Subsequent cleft closure leads to the formation of an unstable pre-open state ‘AR*’ with the agonist bound, cleft closed and channel closed. From this state, transitions to the channel open ‘AO’ or channel desensitized ‘AD’ can occur.

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