Newborn screening for autism: in search of candidate biomarkers

Biomark Med. 2013 Apr;7(2):247-60. doi: 10.2217/bmm.12.108.

Abstract

Background: Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment.

Aim: This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay.

Materials & methods: The present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis.

Results: Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD.

Conclusion: This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Autistic Disorder / blood*
  • Autistic Disorder / diagnosis*
  • Biomarkers
  • Case-Control Studies
  • Child, Preschool
  • Female
  • Humans
  • Immunoassay
  • Infant, Newborn
  • Male
  • Neonatal Screening*
  • Retrospective Studies

Substances

  • Biomarkers