[Clinical role of lipoprotein-associated phospholipase A2]

Kardiologiia. 2013;53(3):59-70.
[Article in Russian]

Abstract

Inflammation plays an important role in origin and progression of atheromatous plaque. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker of inflammation and a predictor of vascular events. Lp-PLA2 is an enzyme secreted by leukocytes and associated with circulating lipoproteins and macrophages in atherosclerotic plaques. Lp-PLA2 hydrolizes phospholipids of oxidized low density lipoproteins and generates two proinflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty acids, which play a major role in the development of atherosclerotic lesions, myocardial infarction and ischemic stroke. Recently the first publications appeared about selective inhibitor of phospholipase A2 - darapladib as a novel therapeutic approach for the treatment of patients with coronary artery disease. However, first results need to be confirmed by ongoing large long-term randomized clinical trials.

Publication types

  • English Abstract
  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase* / antagonists & inhibitors
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase* / metabolism
  • Benzaldehydes / pharmacology
  • Biomarkers / metabolism
  • Fatty Acids, Nonesterified / metabolism
  • Humans
  • Inflammation* / complications
  • Inflammation* / metabolism
  • Leukocytes / enzymology
  • Lipoproteins / metabolism
  • Lysophosphatidylcholines / metabolism
  • Myocardial Infarction* / etiology
  • Myocardial Infarction* / metabolism
  • Myocardial Infarction* / prevention & control
  • Oximes / pharmacology
  • Plaque, Atherosclerotic* / etiology
  • Plaque, Atherosclerotic* / metabolism
  • Stroke* / etiology
  • Stroke* / metabolism
  • Stroke* / prevention & control
  • Therapies, Investigational

Substances

  • Benzaldehydes
  • Biomarkers
  • Fatty Acids, Nonesterified
  • Lipoproteins
  • Lysophosphatidylcholines
  • Oximes
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • darapladib