Polycomb complex recruitment in pluripotent stem cells

Nat Cell Biol. 2013 Apr;15(4):348-50. doi: 10.1038/ncb2723.


The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation*
  • CpG Islands / genetics*
  • Embryonic Stem Cells / physiology*
  • F-Box Proteins / metabolism*
  • Gene Expression Regulation, Developmental*
  • Genes, Developmental*
  • Jumonji Domain-Containing Histone Demethylases / metabolism*
  • Polycomb Repressive Complex 1 / metabolism*


  • F-Box Proteins
  • Jumonji Domain-Containing Histone Demethylases
  • Kdm2b protein, mouse
  • Polycomb Repressive Complex 1