Human papillomavirus infection and the multistage carcinogenesis of cervical cancer

Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):553-60. doi: 10.1158/1055-9965.EPI-12-1406.

Abstract

This short review outlines our understanding of cervical cancer precursors, concentrating on the central etiologic role of persistent human papillomavirus infection. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Transformation, Neoplastic / pathology*
  • Disease Progression
  • Female
  • Humans
  • Papillomaviridae / pathogenicity*
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / virology*
  • Risk Factors
  • Uterine Cervical Neoplasms / etiology*
  • Uterine Cervical Neoplasms / pathology