Post-transcriptional regulatory networks in immunity

Immunol Rev. 2013 May;253(1):253-72. doi: 10.1111/imr.12051.


Post-transcriptional mechanisms that modulate global and/or transcript-specific mRNA stability and translation contribute to the rapid and flexible control of gene expression in immune effector cells. These mechanisms rely on RNA-binding proteins (RBPs) that direct regulatory complexes (e.g. exosomes, deadenylases, decapping complexes, RNA-induced silencing complexes) to the 3'-untranslated regions of specific immune transcripts. Here, we review the surprising variety of post-transcriptional control mechanisms that contribute to gene expression in the immune system and discuss how defects in these pathways can contribute to autoimmune disease.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions / genetics
  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / immunology
  • Humans
  • Lymphocytes / immunology*
  • RNA Interference / immunology*
  • RNA-Binding Proteins / immunology*


  • 3' Untranslated Regions
  • RNA-Binding Proteins