What does S-palmitoylation do to membrane proteins?

FEBS J. 2013 Jun;280(12):2766-74. doi: 10.1111/febs.12263. Epub 2013 Apr 18.


S-palmitoylation is post-translational modification, which consists in the addition of a C16 acyl chain to cytosolic cysteines and which is unique amongst lipid modifications in that it is reversible. It can thus, like phosphorylation or ubiquitination, act as a switch. While palmitoylation of soluble proteins allows them to interact with membranes, the consequences of palmitoylation for transmembrane proteins are more enigmatic. We briefly review the current knowledge regarding the enzymes responsible for palmitate addition and removal. We then describe various observed consequences of membrane protein palmitoylation. We propose that the direct effects of palmitoylation on transmembrane proteins, however, might be limited to four non-mutually exclusive mechanistic consequences: alterations in the conformation of transmembrane domains, association with specific membrane domains, controlled interactions with other proteins and controlled interplay with other post-translational modifications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acyltransferases / physiology
  • Animals
  • Humans
  • Lipoylation
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Palmitic Acid / metabolism*
  • Protein Binding
  • Protein Processing, Post-Translational*
  • Protein Structure, Tertiary


  • Membrane Proteins
  • Palmitic Acid
  • Acyltransferases