Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases

J Neurol. 1990 Apr;237(2):113-6. doi: 10.1007/BF00314674.


Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Central Nervous System / pathology*
  • Female
  • Humans
  • Lyme Disease / complications
  • Lyme Disease / pathology*
  • Male
  • Middle Aged
  • Nervous System Diseases / etiology
  • Nervous System Diseases / pathology*
  • Peripheral Nerves / pathology*
  • Vasculitis / etiology
  • Vasculitis / pathology