An archaeal homolog of proteasome assembly factor functions as a proteasome activator

PLoS One. 2013;8(3):e60294. doi: 10.1371/journal.pone.0060294. Epub 2013 Mar 21.

Abstract

Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical architecture. Recent bioinformatic analysis identified archaeal PAC1-PAC2 homologs PbaA and PbaB. However, it remains unclear whether such assembly factor-like proteins play an indispensable role in orchestration of proteasome subunits in archaea. We revealed that PbaB forms a homotetramer and exerts a dual function as an ATP-independent proteasome activator and a molecular chaperone through its tentacle-like C-terminal segments. Our findings provide insights into molecular evolution relationships between proteasome activators and assembly factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Archaea / metabolism*
  • Archaeal Proteins / metabolism*
  • Evolution, Molecular
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Binding

Substances

  • Archaeal Proteins
  • Proteasome Endopeptidase Complex

Grants and funding

This work was supported in part by the Targeted Proteins Research Program (to TM and K. Kato) and Grants-in-Aid for Scientific Research (to TS, TM, YK, SU and K. Kato) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.