Functional cerebral imaging by susceptibility-contrast NMR

Magn Reson Med. 1990 Jun;14(3):538-46. doi: 10.1002/mrm.1910140311.


In vivo measurement of cerebral physiology by dynamic contrast-enhanced NMR is demonstrated. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility-induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Volume
  • Brain / metabolism*
  • Brain / physiology
  • Cerebrovascular Circulation*
  • Contrast Media / metabolism
  • Dogs
  • Magnetic Resonance Spectroscopy / methods*


  • Contrast Media