Anabolic resistance of muscle protein synthesis with aging

Exerc Sport Sci Rev. 2013 Jul;41(3):169-73. doi: 10.1097/JES.0b013e318292f3d5.


Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed "anabolic resistance." Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Amino Acids / blood
  • Eating
  • Exercise / physiology*
  • Humans
  • Muscle Proteins / biosynthesis*
  • Postprandial Period / physiology*


  • Amino Acids
  • Muscle Proteins