Exendin-4 attenuates ischemia-induced ventricular arrhythmias in rats

Cardiol J. 2013;20(1):29-33. doi: 10.5603/CJ.2013.0006.


Background: Glucagon-like peptide-1 and its receptor agonist-exendin-4 (Ex-4) have been shown to provide beneficial effects for cardiovascular diseases. This study investigated the effects of Ex-4 on ischemia-induced ventricular arrhythmias in rats.

Methods: Anesthetized male rats were once treated with Ex-4 (5 μg/kg, i.v.) 1 h before ischemia in the absence and/or presence of 5-hydroxydecanoic acid (5-HD, 10 mg/kg, i.v., a specific inhibitor of mitochondrial ATP-sensitive potassium [KATP] channels) which were once injected 10 min before ischemia. And then subjected to ischemia for 30 min. Ventricular arrhythmias were assessed.

Results: During the 30-min ischemia, Ex-4 significantly reduced the incidence of ventricular fibrillation (VF) (p < 0.05). The duration of ventricular tachycardia (VT) + VF, the number of VT + VF episodes and the severity of arrhythmias were all significantly reduced by Ex-4 compared to those in myocardial ischemia group (p < 0.05 for all). Administration of 5-HD abolished the protective effects of Ex-4 on VF incidence, the duration of VT + VF, the number of VT + VF episodes and the severity of arrhythmias (p < 0.05 for all).

Conclusions: This study suggested that Ex-4 could attenuate ischemia-induced ventricular arrhythmias in rats in which mitochondrial KATP channels may be involved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / pharmacology
  • Blood Pressure / drug effects
  • Decanoic Acids / pharmacology
  • Disease Models, Animal
  • Exenatide
  • Heart Rate / drug effects
  • Hydroxy Acids / pharmacology
  • Hypoglycemic Agents / pharmacology
  • Male
  • Myocardial Ischemia / complications
  • Myocardial Ischemia / drug therapy*
  • Peptides / pharmacology*
  • Potassium Channel Blockers / pharmacology
  • Potassium Channels / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Tachycardia, Ventricular / drug therapy*
  • Tachycardia, Ventricular / etiology
  • Venoms / pharmacology*
  • Ventricular Fibrillation / drug therapy*
  • Ventricular Fibrillation / etiology


  • Anti-Arrhythmia Agents
  • Decanoic Acids
  • Hydroxy Acids
  • Hypoglycemic Agents
  • Peptides
  • Potassium Channel Blockers
  • Potassium Channels
  • Venoms
  • mitochondrial K(ATP) channel
  • 5-hydroxydecanoic acid
  • Exenatide