The glucagon-stimulated C-peptide test: an aid in classification of patients with diabetes mellitus

Neth J Med. 1990 Apr;36(3-4):196-9.


Ninety-eight patients with diabetes mellitus (52 women and 46 men) underwent a glucagon stimulated C-peptide test. Treatment was instigated on the basis of classical criteria, independent of the test results, and remained unchanged during a 2-yr test period. The type of treatment and metabolic control were then related to the test results. Fasting C-peptide concentrations do not discriminate between insulin dependent and non-insulin dependent diabetes mellitus. C-peptide concentrations 10 min after intravenous injection of 1 mg of glucagon, however, correctly classified the patients. With the help of this test, the correct model of treatment for patients with diabetes mellitus can be chosen.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • C-Peptide / blood*
  • Diabetes Mellitus / classification*
  • Female
  • Glucagon*
  • Glycated Hemoglobin A / analysis
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged


  • Blood Glucose
  • C-Peptide
  • Glycated Hemoglobin A
  • Glucagon