Chemotherapy-induced takotsubo cardiomyopathy

Heart Fail Clin. 2013 Apr;9(2):233-42, x. doi: 10.1016/j.hfc.2012.12.009. Epub 2013 Jan 23.


Stress cardiomyopathy, also known as takotsubo cardiomyopathy, is a rapidly reversible form of acute heart failure classically triggered by stressful events. It is associated with a distinctive left ventricular contraction pattern described as apical akinesis/ballooning with hyperdynamic contraction of the basal segments in the absence of obstructive coronary artery disease. The traditional paradigm has expanded to include other causes, in particular chemotherapeutic drugs. The literature increasingly suggests an association between cancer, chemotherapeutic drugs, and stress cardiomyopathy. Chemotherapy-induced takotsubo cardiomyopathy is a relatively new phenomenon, but one that merits detailed attention to the elucidation of possible mechanistic links.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Monoclonal, Murine-Derived / adverse effects*
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antimetabolites, Antineoplastic / adverse effects
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Echocardiography
  • Electrocardiography
  • Female
  • Fluorouracil / adverse effects
  • Humans
  • Lymphoma / drug therapy*
  • Middle Aged
  • Rituximab
  • Stroke Volume / physiology
  • Takotsubo Cardiomyopathy / chemically induced*
  • Takotsubo Cardiomyopathy / diagnosis
  • Takotsubo Cardiomyopathy / physiopathology
  • Ventricular Dysfunction, Left / chemically induced
  • Ventricular Dysfunction, Left / diagnosis
  • Ventricular Dysfunction, Left / physiopathology


  • Antibodies, Monoclonal, Murine-Derived
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Rituximab
  • Fluorouracil