Consensus paper: current views on the role of cerebellar interpositus nucleus in movement control and emotion

Cerebellum. 2013 Oct;12(5):738-57. doi: 10.1007/s12311-013-0464-0.


In the present paper, we examine the role of the cerebellar interpositus nucleus (IN) in motor and non-motor domains. Recent findings are considered, and we share the following conclusions: IN as part of the olivo-cortico-nuclear microcircuit is involved in providing powerful timing signals important in coordinating limb movements; IN could participate in the timing and performance of ongoing conditioned responses rather than the generation and/or initiation of such responses; IN is involved in the control of reflexive and voluntary movements in a task- and effector system-dependent fashion, including hand movements and associated upper limb adjustments, for quick effective actions; IN develops internal models for dynamic interactions of the motor system with the external environment for anticipatory control of movement; and IN plays a significant role in the modulation of autonomic and emotional functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Cerebellar Nuclei / physiology*
  • Cerebral Cortex / physiology*
  • Emotions / physiology*
  • Humans
  • Movement / physiology*