Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties

Food Chem Toxicol. 2013 Nov;61:112-20. doi: 10.1016/j.fct.2013.03.038. Epub 2013 Apr 6.

Abstract

Dietary stilbenes comprise a class of natural compounds that display significant biological activities of medicinal interest. Among them, their antioxidant, anti-aging and anti-angiogenesic properties are well established and subjects of numerous research endeavors. This mini-review aspires to account and present the literature reports published on research concerning various natural and synthetic stilbenes, such as trans-resveratrol. Special focus was given to most recent research findings, while the mechanisms underlying their anti-aging and anti-angiogenic effects as well as the respective signaling pathways involved were also presented and discussed.

Keywords: Aging; Angiogenesis; Lifespan; Polyphenol; Resveratrol; Stilbenes.

Publication types

  • Review

MeSH terms

  • Aging / drug effects*
  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / pharmacology
  • Dibenzocycloheptenes / pharmacology
  • Dietary Supplements
  • Humans
  • Plants / chemistry
  • Resorcinols / pharmacology
  • Resveratrol
  • Rodentia
  • Stilbenes / chemistry
  • Stilbenes / isolation & purification
  • Stilbenes / pharmacology*

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents, Phytogenic
  • Benzofurans
  • Dibenzocycloheptenes
  • N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine
  • Resorcinols
  • Stilbenes
  • amurensin G
  • pterostilbene
  • 3,3',4,5'-tetrahydroxystilbene
  • Resveratrol