Ampicillin and Amoxicillin Use and the Risk of Klebsiella Pneumoniae Liver Abscess in Taiwan

J Infect Dis. 2013 Jul 15;208(2):211-7. doi: 10.1093/infdis/jit157. Epub 2013 Apr 8.

Abstract

Background: Klebsiella pneumoniae liver abscess (KPLA) is prevalent in East Asia. Use of amoxicillin/ampicillin may lead to overgrowth of K. pneumoniae in the intestine and predispose to KPLA. We used an animal study and nationwide population-based database to investigate the association between ampicillin/amoxicillin use and KPLA in Taiwan.

Methods: In an animal study, ampicillin or sterile water was administered orogastrically in serotype K1 K. pneumoniae-colonized mice and the outcome was compared. We identified 855 cases with liver abscess and selected 3420 age- and sex-matched control subjects from the National Health Insurance Research Database. Conditional logistic regression was used to estimate the adjusted odds ratios (ORs) for the association between recent use of ampicillin/amoxicillin and KPLA.

Results: Ampicillin administration predisposed K. pneumoniae-colonized mice to increased bacterial burden, liver abscess and necrosis, and lethality. The population-based study showed that the adjusted OR associating the use of ampicillin/amoxicillin within the past 30 days with KPLA was 3.5 (95% confidence interval, 2.5-5.1). No association was found with use in the past 31-90 days.

Conclusions: Ampicillin/amoxicillin therapy started within the past 30 days was associated with increased risk for KPLA. We should avoid the overuse of these antibiotics to prevent undesired disease in the endemic area.

Keywords: Klebsiella pneumoniae; amoxicillin; ampicillin; liver abscess.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / adverse effects*
  • Ampicillin / adverse effects*
  • Animals
  • Female
  • Humans
  • Klebsiella Infections / chemically induced*
  • Klebsiella Infections / epidemiology
  • Klebsiella Infections / genetics
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / growth & development
  • Liver Abscess / chemically induced*
  • Liver Abscess / epidemiology
  • Liver Abscess / genetics
  • Liver Abscess / microbiology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Risk
  • Serotyping / methods
  • Taiwan / epidemiology

Substances

  • Ampicillin
  • Amoxicillin