Neo-sex chromosomes and adaptive potential in tortricid pests

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6931-6. doi: 10.1073/pnas.1220372110. Epub 2013 Apr 8.


Changes in genome architecture often have a significant effect on ecological specialization and speciation. This effect may be further enhanced by involvement of sex chromosomes playing a disproportionate role in reproductive isolation. We have physically mapped the Z chromosome of the major pome fruit pest, the codling moth, Cydia pomonella (Tortricidae), and show that it arose by fusion between an ancestral Z chromosome and an autosome corresponding to chromosome 15 in the Bombyx mori reference genome. We further show that the fusion originated in a common ancestor of the main tortricid subfamilies, Olethreutinae and Tortricinae, comprising almost 700 pest species worldwide. The Z-autosome fusion brought two major genes conferring insecticide resistance and clusters of genes involved in detoxification of plant secondary metabolites under sex-linked inheritance. We suggest that this fusion significantly increased the adaptive potential of tortricid moths and thus contributed to their radiation and subsequent speciation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptation, Biological / genetics*
  • Animals
  • Base Sequence
  • Chromosomes, Artificial, Bacterial
  • Evolution, Molecular*
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Moths / genetics*
  • Physical Chromosome Mapping
  • Sequence Analysis, DNA
  • Sex Chromosomes / genetics*
  • Translocation, Genetic / genetics*

Associated data

  • GENBANK/JQ771334
  • GENBANK/JQ771335
  • GENBANK/JQ771337
  • GENBANK/JQ771338
  • GENBANK/JQ771339
  • GENBANK/JQ771341
  • GENBANK/JQ771343
  • GENBANK/JQ771344
  • GENBANK/JQ771346
  • GENBANK/JQ771353
  • GENBANK/JQ771354
  • GENBANK/JQ771355
  • GENBANK/JQ771357
  • GENBANK/JQ771358
  • GENBANK/JQ771360
  • GENBANK/JQ771361
  • GENBANK/JQ771362
  • GENBANK/JQ771363
  • GENBANK/JQ771368
  • GENBANK/JQ771369
  • GENBANK/JX258662
  • GENBANK/JX258665
  • GENBANK/JX258666
  • GENBANK/JX258667
  • GENBANK/JX258668
  • GENBANK/JX307647