trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro

Comp Biochem Physiol A Mol Integr Physiol. 2013 Jul;165(3):313-8. doi: 10.1016/j.cbpa.2013.03.040. Epub 2013 Apr 6.


trans-Resveratrol and ε-viniferin are used as dietary supplements. They are reported to be supportive in preventing arteriosclerosis and diabetes and a previous study could demonstrate an inhibitory potential on sodium-dependent glucose transport (SGLT1) in oocytes und mouse intestinal everted rings (Schulze et al., 2012, Genes Nutr. 6, S61). The in vitro effects of trans-resveratrol and ε-viniferin on intestinal glucose uptake in the porcine small intestines (Sus Scrofa) have not yet been evaluated. It was hypothesized that trans-resveratrol/ε-viniferin may have an adverse effect on porcine intestinal sodium-dependent glucose uptake. The effects on electrogenic small intestinal glucose absorption and sodium-dependent (3)H-glucose uptake in brush border membrane vesicles (BBMV) were evaluated. Pieces of mucosa were mounted into Ussing chambers and were incubated with either trans-resveratrol (0.3 mmol/L), ε-viniferin (0.3 mmol/L), or ethanol. Sodium-dependent glucose absorption into BBMV was measured. (3)H-glucose uptake studies were performed using the same concentrations of the respective substances. SGLT1-mediated glucose absorption was approximately 3-fold higher in ileum compared to jejunum. After preincubation with trans-resveratrol and ε-viniferin, glucose-induced increases of short-circuit currents were significantly decreased. BBMV-studies revealed comparable results and glucose uptake was also significantly decreased. As the glucose transport/uptake was decreased after preincubation with either trans-resveratrol or ε-viniferin this active transport mechanism was directly influenced by inhibiting the SGLT1 transport system.

MeSH terms

  • Animals
  • Benzofurans / pharmacology*
  • Biological Transport, Active / drug effects
  • Glucose / metabolism*
  • Ileum / drug effects*
  • Ileum / metabolism*
  • Intestinal Absorption / drug effects
  • Intestinal Mucosa / metabolism
  • Jejunum / drug effects*
  • Jejunum / metabolism*
  • Male
  • Resveratrol
  • Sodium-Glucose Transporter 1 / metabolism
  • Stilbenes / pharmacology*
  • Swine / metabolism


  • Benzofurans
  • Sodium-Glucose Transporter 1
  • Stilbenes
  • epsilon-viniferin
  • Glucose
  • Resveratrol