We tested the ability of an ultraviolet C (UV-C)-reflective wall coating to reduce the time necessary to decontaminate a room using a UV-C-emitting device (Tru-D SmartUVC). The reflective wall coating provided the following time reductions for decontamination: for methicillin-resistant Staphylococcus aureus, from 25 minutes 13 seconds to 5 minutes 3 seconds ([Formula: see text]), and for Clostridium difficile spores, from 43 minutes 42 seconds to 9 minutes 24 seconds ([Formula: see text]).