Magnetic resonance imaging in Parkinson's disease

Arch Neurol. 1990 Jul;47(7):735-7. doi: 10.1001/archneur.1990.00530070023006.


Magnetic resonance imaging was utilized to examine changes in the pars compacta associated with Parkinson's disease. We found a reduction in average width of the pars compacta in advanced- but not early-stage patients. Conversely, a significant difference in width (right minus left) was observed in early- but not late-stage patients. Width asymmetry may be a sensitive magnetic resonance imaging indicator for the early detection of Parkinson's disease when there is a predominance of unilateral clinical symptoms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Brain / pathology*
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis*