Abstract
Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteriocins / pharmacology*
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Bacteriocins / therapeutic use
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Clostridioides difficile / drug effects*
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Clostridioides difficile / isolation & purification
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Depsipeptides / pharmacology*
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Depsipeptides / therapeutic use
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Drug Synergism
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Drug Therapy, Combination
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Enterocolitis, Pseudomembranous / drug therapy
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Enterocolitis, Pseudomembranous / microbiology*
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Humans
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Metronidazole / pharmacology
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Metronidazole / therapeutic use
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Microbial Sensitivity Tests / standards
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Peptides / pharmacology*
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Peptides / therapeutic use
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Vancomycin / pharmacology
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Bacteriocins
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Depsipeptides
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Peptides
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ramoplanin
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Metronidazole
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thuricin
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gardimycin
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Vancomycin