Islet amyloid polypeptide, a novel pancreatic peptide, is a circulating hormone secreted under glucose stimulation

Biochem Biophys Res Commun. 1990 Jun 15;169(2):713-8. doi: 10.1016/0006-291x(90)90389-5.


Islet amyloid polypeptide (IAPP) was identified in human plasma using immunoaffinity chromatography, gel filtration and reverse- phase high performance liquid chromatography coupled with radioimmunoassay specific for the peptide. IAPP[1-37], IAPP[17-37], and other two IAPP- related peptides which were putative pro-IAPPs or different processing products of IAPP, were isolated. All of these IAPPs were also found in human pancreatic extract, indicating that they were secreted from B cell secretory granules into the circulation. IAPP[1-37] is a major molecular form of IAPP in the pancreas, but it accounted for 31% of immunoreactive IAPP in the plasma. Plasma concentration of IAPP in normal individuals increased to 3.0 times the basal level in response to oral administration of 75 g glucose. This study indicated that IAPP is a circulating hormone secreted under glucose stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amyloid / analysis
  • Amyloid / blood*
  • Amyloid / metabolism
  • Chromatography, Affinity
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Fasting
  • Glucose
  • Humans
  • Immunoglobulin G
  • Islet Amyloid Polypeptide
  • Kinetics
  • Male
  • Pancreas / analysis
  • Pancreas / pathology
  • Radioimmunoassay
  • Reference Values


  • Amyloid
  • Immunoglobulin G
  • Islet Amyloid Polypeptide
  • Glucose