Ultrasonic synthesis, characterization of β-aminoketones by bismuth(III) triflate and determination of antigenotoxic properties

Toxicol Ind Health. 2015 Oct;31(10):911-9. doi: 10.1177/0748233713484649. Epub 2013 Apr 9.

Abstract

Direct-type catalytic Mannich reaction for the synthesis of β-aminoketones from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes has been applied in water with bismuth triflate under ultrasound. Good yields of the expected β-aminoketones were obtained from available substrates, at room temperature in 1-2 hours. This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized β-aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems.

Keywords: antigenotoxic properties; bismuth(III) triflate; direct-type Mannich reaction; ultrasonic synthesis; β-aminoketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / drug effects
  • Bacteria / genetics
  • Ketones / chemical synthesis
  • Ketones / pharmacology*
  • Mesylates / chemistry*
  • Microbial Viability / drug effects
  • Mutagens / pharmacology*
  • Mutation / drug effects
  • Protective Agents / chemical synthesis
  • Protective Agents / pharmacology*
  • Sonication

Substances

  • Ketones
  • Mesylates
  • Mutagens
  • Protective Agents
  • Bi(OTf)3