C(sp3)-H bond arylations catalyzed by well-defined [Ru(O2CMes)2(p-cymene)]

N Y Phani Kumar; Rajkumar Jeyachandran; Lutz Ackermann

doi:10.1021/jo400658d

C(sp3)-H bond arylations catalyzed by well-defined [Ru(O2CMes)2(p-cymene)]

J Org Chem. 2013 Apr 19;78(8):4145-52. doi: 10.1021/jo400658d. Epub 2013 Apr 10.

Authors

N Y Phani Kumar¹, Rajkumar Jeyachandran, Lutz Ackermann

Affiliation

¹ Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany.

PMID: 23574572
DOI: 10.1021/jo400658d

Abstract

The well-characterized ruthenium(II) biscarboxylate complex [Ru(O2CMes)2(p-cymene)] enabled versatile direct (hetero)arylations of C(sp(3))-H bonds with low (co)catalyst loading and ample substrate scope. Detailed mechanistic studies provided strong support for a facile and reversible C(sp(3))-H bond metalation.