Immunoreactive interleukin-1 beta localization in the rat forebrain

Brain Res. 1990 Apr 23;514(1):135-40. doi: 10.1016/0006-8993(90)90445-h.


To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Frontal Lobe / cytology
  • Frontal Lobe / metabolism*
  • Immunohistochemistry
  • Interleukin-1 / metabolism*
  • Rabbits


  • Interleukin-1