New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population

J Hum Genet. 2013 Jun;58(6):362-5. doi: 10.1038/jhg.2013.14. Epub 2013 Apr 11.


Most recently, 1-h hyperglycemia has been recognized as an additional risk factor for type 2 diabetes. To date, previous genome-wide association studies for glycemic traits have a limited impact on the fasting state and 2-h plasma glucose level in an oral glucose challenge. To identify genetic susceptibility in different stages of glucose tolerance, we performed a meta-analysis for glycemic traits including 1-h plasma glucose (1-hPG) from 14 232 non-diabetic individuals in the Korean population. Newly implicated variants (MYL2, C12orf51 and OAS1) were found to be significantly associated with 1-hPG. We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / genetics*
  • Adult
  • Aged
  • Asian People / genetics*
  • Blood Glucose / analysis
  • Cardiac Myosins / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes, Gestational / genetics
  • Fasting / blood
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Genotype
  • Glucose Tolerance Test
  • Humans
  • Hyperglycemia / blood
  • Linear Models
  • Male
  • Middle Aged
  • Myosin Light Chains / genetics*
  • Polymorphism, Single Nucleotide
  • Pregnancy
  • Republic of Korea
  • Risk Factors
  • Ubiquitin-Protein Ligases / genetics*


  • Blood Glucose
  • Myosin Light Chains
  • myosin light chain 2
  • Ubiquitin-Protein Ligases
  • OAS1 protein, human
  • 2',5'-Oligoadenylate Synthetase
  • Cardiac Myosins