A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

Dalton Trans. 2013 Jun 14;42(22):8066-9. doi: 10.1039/c3dt50194a. Epub 2013 Apr 10.


A europium(III) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen ((1)O2). The water soluble, thermodynamically stable complex reacts rapidly with (1)O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(III)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry
  • Contrast Media / chemistry*
  • Europium / chemistry*
  • HeLa Cells
  • Heterocyclic Compounds, 1-Ring / chemistry*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Singlet Oxygen / analysis*


  • Amides
  • Contrast Media
  • Heterocyclic Compounds, 1-Ring
  • Singlet Oxygen
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Europium