Antigenic expression of cathepsin B in aged human brain

Brain Res Bull. 1990 Apr;24(4):543-9. doi: 10.1016/0361-9230(90)90157-u.


The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Brain / growth & development
  • Brain / metabolism*
  • Brain / pathology
  • Cathepsin B / metabolism*
  • Humans
  • Immunohistochemistry
  • Middle Aged


  • Cathepsin B