Molecular Optical Simulation Environment (MOSE): a platform for the simulation of light propagation in turbid media

Shenghan Ren; Xueli Chen; Hailong Wang; Xiaochao Qu; Ge Wang; Jimin Liang; Jie Tian

doi:10.1371/journal.pone.0061304

Molecular Optical Simulation Environment (MOSE): a platform for the simulation of light propagation in turbid media

PLoS One. 2013;8(4):e61304. doi: 10.1371/journal.pone.0061304. Epub 2013 Apr 8.

Authors

Shenghan Ren¹, Xueli Chen, Hailong Wang, Xiaochao Qu, Ge Wang, Jimin Liang, Jie Tian

Affiliation

¹ School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.

Abstract

The study of light propagation in turbid media has attracted extensive attention in the field of biomedical optical molecular imaging. In this paper, we present a software platform for the simulation of light propagation in turbid media named the "Molecular Optical Simulation Environment (MOSE)". Based on the gold standard of the Monte Carlo method, MOSE simulates light propagation both in tissues with complicated structures and through free-space. In particular, MOSE synthesizes realistic data for bioluminescence tomography (BLT), fluorescence molecular tomography (FMT), and diffuse optical tomography (DOT). The user-friendly interface and powerful visualization tools facilitate data analysis and system evaluation. As a major measure for resource sharing and reproducible research, MOSE aims to provide freeware for research and educational institutions, which can be downloaded at http://www.mosetm.net.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electrical Equipment and Supplies
Light*
Mice
Monte Carlo Method*
Optical Phenomena*
Phantoms, Imaging
Time Factors
Tomography, Optical

Grants and funding

This work was supported by the Program of the National Basic Research and Development Program of China (973) under Grant No. 2011CB707702, the National Natural Science Foundation of China under Grant Nos. 81090272, 81227901, 81101083, and the Fundamental Research Funds for the Central Universities. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.