Lymphatic vessel memory stimulated by recurrent inflammation

Am J Pathol. 2013 Jun;182(6):2418-28. doi: 10.1016/j.ajpath.2013.02.025. Epub 2013 Apr 8.

Abstract

Inflammation stimulates new lymphatic vessel growth (inflammatory lymphangiogenesis). One key question is how recurrent inflammation, a common clinical condition, regulates lymphatic vessel remodeling. We show here that recurrent inflammation accelerated the development a functional lymphatic vessel network. This observation suggests a novel program of lymphangiogenesis and identifies a property of lymphatic vessel memory in response to recurrent inflammation. A brief episode of initial inflammation regressed lymphatic vessels, and a significant increase in CD11b(+) macrophages were associated with the development of lymphatic vessel memory. These vessels had major differences in the structure and the spatial distribution of specialized lymphatic vessel features. Surprisingly, we found that the lymphatic vessel memory response did not depend on the vascular endothelial growth factor C or A pathway, indicating that different molecular pathways regulate inflammatory lymphangiogenesis and lymphatic vessel memory. These findings uncover a priming mechanism to facilitate a rapid lymphatic vessel memory response: a potential important component of peripheral host defense.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD11b Antigen / analysis
  • Disease Models, Animal
  • Histocompatibility Antigens Class II / analysis
  • Keratitis / immunology
  • Keratitis / pathology
  • Keratitis / physiopathology*
  • Lymphangiogenesis / physiology*
  • Lymphatic Vessels / pathology*
  • Lymphatic Vessels / physiopathology
  • Macrophages / immunology
  • Mice
  • Microscopy, Fluorescence
  • Recurrence
  • Vascular Endothelial Growth Factor A / physiology
  • Vascular Endothelial Growth Factor C / physiology
  • Wound Healing / physiology

Substances

  • CD11b Antigen
  • Histocompatibility Antigens Class II
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor C
  • vascular endothelial growth factor A, mouse
  • vascular endothelial growth factor C, mouse