Perspective on fever: the basic science and conventional medicine

Complement Ther Med. 2013 Apr;21 Suppl 1:S54-60. doi: 10.1016/j.ctim.2011.08.002. Epub 2011 Sep 17.


This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.

Publication types

  • Review

MeSH terms

  • Body Temperature / immunology*
  • Body Temperature Regulation / immunology*
  • Cytokines / metabolism*
  • Fever / immunology*
  • Fever / metabolism
  • Humans
  • Infections / immunology*
  • Infections / metabolism
  • Macrophages / metabolism
  • Monocytes / metabolism
  • Wounds and Injuries / immunology
  • Wounds and Injuries / metabolism


  • Cytokines