Although it is widely recognised that America was the last continent to be populated by our species, researchers' views on various aspects of this process (e.g. the period in which it occurred, the area from which the colonizing populations came, the number of dispersal waves and the routes taken by these migrations) differ significantly. In this paper, we review both classical data and more recent findings from various research fields - including geology, paleoecology, archaeology, skeletal biology, and genetics - that may shed light on the dynamics of the colonization of the American continent, according to a critical reappraisal of the various hypotheses and models that have been advanced over time to explain this process.