Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation

Phytother Res. 2014 Jan;28(1):137-43. doi: 10.1002/ptr.4965. Epub 2013 Apr 12.

Abstract

This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor γ, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity.

Keywords: antiobesity; fat accumulation; fucoidan; steatosis.

MeSH terms

  • Acetyl-CoA Carboxylase / genetics
  • Acetyl-CoA Carboxylase / metabolism
  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Cholesterol / blood
  • Diet, High-Fat / adverse effects
  • Dietary Supplements*
  • Down-Regulation / drug effects
  • Epididymis / drug effects
  • Fatty Acid-Binding Proteins / genetics
  • Fatty Acid-Binding Proteins / metabolism
  • Lipoproteins, LDL / blood
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity / drug therapy*
  • Obesity / metabolism
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Polysaccharides / pharmacology*
  • Triglycerides / blood

Substances

  • Anti-Obesity Agents
  • Fatty Acid-Binding Proteins
  • Lipoproteins, LDL
  • PPAR gamma
  • Polysaccharides
  • Triglycerides
  • fucoidan
  • Cholesterol
  • Acetyl-CoA Carboxylase