Abstract
An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development of novel treatments for patients with high levels of low-density lipoproteins in their blood.
Keywords:
COP II; Cholesterol metabolism; Mouse; Secretory pathway.
MeSH terms
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Animals
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COP-Coated Vesicles / enzymology*
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Cholesterol / blood*
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Dyslipidemias / enzymology*
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Endoplasmic Reticulum / enzymology*
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Humans
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Liver / enzymology*
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Proprotein Convertase 9
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Proprotein Convertases / blood*
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Serine Endopeptidases / blood*
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Vesicular Transport Proteins / deficiency*
Substances
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Vesicular Transport Proteins
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Cholesterol
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Pcsk9 protein, mouse
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Proprotein Convertase 9
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Proprotein Convertases
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Serine Endopeptidases