Opening up new fronts in the fight against cholesterol

Elife. 2013 Apr 9:2:e00663. doi: 10.7554/eLife.00663.

Abstract

An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development of novel treatments for patients with high levels of low-density lipoproteins in their blood.

Keywords: COP II; Cholesterol metabolism; Mouse; Secretory pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • COP-Coated Vesicles / enzymology*
  • Cholesterol / blood*
  • Dyslipidemias / enzymology*
  • Endoplasmic Reticulum / enzymology*
  • Humans
  • Liver / enzymology*
  • Proprotein Convertase 9
  • Proprotein Convertases / blood*
  • Serine Endopeptidases / blood*
  • Vesicular Transport Proteins / deficiency*

Substances

  • Vesicular Transport Proteins
  • Cholesterol
  • Pcsk9 protein, mouse
  • Proprotein Convertase 9
  • Proprotein Convertases
  • Serine Endopeptidases