CCRL2, a fringe member of the atypical chemoattractant receptor family

Eur J Immunol. 2013 Jun;43(6):1418-22. doi: 10.1002/eji.201243179. Epub 2013 May 10.


The term atypical chemoattractant receptors is generally used to refer to a subset of G-protein-coupled receptors devoid of chemotactic activity and characterized by the ability to scavenge chemotactic factors from the inflammatory milieu. However, emerging evidence suggests that this class of receptors is heterogeneous in function. In this Viewpoint, we discuss the properties of CCRL2, a molecule devoid of ligand scavenging functions and suggested to regulate leukocyte recruitment by alternative mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cellular Microenvironment
  • Chemotactic Factors / immunology*
  • Chemotaxis
  • Humans
  • Immunomodulation
  • Inflammation / metabolism
  • Leukocytes / immunology*
  • Protein Binding
  • Receptors, CCR / immunology
  • Receptors, CCR / metabolism*
  • Receptors, G-Protein-Coupled / immunology*


  • CCRL2 protein, human
  • Chemotactic Factors
  • Receptors, CCR
  • Receptors, G-Protein-Coupled