Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices

ACS Chem Neurosci. 2013 May 15;4(5):693-703. doi: 10.1021/cn400026v. Epub 2013 May 6.


Fast scan cyclic voltammetry in brain slices (slice voltammetry) has been used over the last several decades to increase substantially our understanding of the complex local regulation of dopamine release and uptake in the striatum. This technique is routinely used for the study of changes that occur in the dopamine system associated with various disease states and pharmacological treatments, and to study mechanisms of local circuitry regulation of dopamine terminal function. In the context of this Review, we compare the relative advantages of voltammetry using striatal slice preparations versus in vivo preparations, and highlight recent advances in our understanding of dopamine release and uptake in the striatum specifically from studies that use slice voltammetry in drug-naïve animals and animals with a history of psychostimulant self-administration.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / physiology
  • Dopaminergic Neurons / metabolism*
  • Dopaminergic Neurons / physiology
  • Electrochemical Techniques / methods*
  • Humans
  • In Vitro Techniques
  • Neostriatum / metabolism
  • Neostriatum / physiology*
  • Neuronal Plasticity


  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine