Trans-canal laser irradiation reduces tinnitus perception of salicylate treated rat

Neurosci Lett. 2013 Jun 7;544:131-5. doi: 10.1016/j.neulet.2013.03.058. Epub 2013 Apr 11.


The aim of this study was to find out the effect of low-level laser therapy (LLLT) on salicylate-induced tinnitus in the rat model. Fourteen Sprague-Dawley rats (8 weeks; 240-280 gm) were divided into 2 groups (study group, control group). Rats of both groups were treated with 400 mg/kg/day of sodium salicylate for 8 consecutive days. Tinnitus was monitored using GPIAS (Gap Prepulse Inhibition of Acoustic Startle) 2 h after first salicylate treatment, and every 24 h during 9 days of treatment. Rats in laser group were irradiated to each ear with wavelength of 830 nm diode laser (165 mW/cm(2)) for 30 min daily for 8 days. During salicylate treatment, rats of study group irradiated with low level laser showed significantly higher GPIAS values throughout the experiment. Therapeutic effect of LLLT is demonstrated in animal tinnitus model by means of GPIAS. Further experimental studies are needed to find possible mechanisms and better methods to improve LLLT efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Low-Level Light Therapy / methods*
  • Rats
  • Rats, Sprague-Dawley
  • Reflex, Startle / radiation effects*
  • Salicylates*
  • Tinnitus / chemically induced
  • Tinnitus / physiopathology*
  • Tinnitus / radiotherapy*
  • Treatment Outcome


  • Salicylates