Effect of ascorbic acid on plasma alcohol clearance

J Am Coll Nutr. 1990 Jun;9(3):185-9. doi: 10.1080/07315724.1990.10720368.


The effects of short-term and long-term ascorbic acid supplements on plasma alcohol clearance were studied in 13 clinically healthy male subjects. Two dose levels of alcohol, 0.5 and 0.8 g/kg body weight, were used. Blood samples were taken at zero time, 0.5 hours, then hourly up to 6 hours after alcohol consumption for the measurement of plasma alcohol and ascorbic acid levels, red-cell reduced glutathione level, and plasma alanine aminotransferase activity. At both dosages of alcohol, short-term as well as long-term pretreatment with ascorbic acid significantly enhanced the clearance of plasma alcohol. Although long-term ascorbic acid pretreatment resulted in better alcohol clearance, no significant difference in alcohol clearance was found between short-term and long-term ascorbic acid pretreatment. The two dose levels of alcohol had no significant effect on the red-cell reduced glutathione concentration or plasma alanine aminotransferase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Alcohol Drinking*
  • Ascorbic Acid / blood
  • Ascorbic Acid / pharmacology*
  • Dose-Response Relationship, Drug
  • Erythrocytes / metabolism
  • Ethanol / blood*
  • Ethanol / pharmacokinetics
  • Glutathione / metabolism
  • Humans
  • Male
  • Middle Aged


  • Ethanol
  • Alanine Transaminase
  • Glutathione
  • Ascorbic Acid