LKB1 and AMPK and the cancer-metabolism link - ten years after

BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36.

Abstract

The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Energy Metabolism
  • Humans
  • Neoplasms / enzymology
  • Neoplasms / metabolism*
  • Neoplasms / prevention & control
  • Neoplasms / therapy
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction

Substances

  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases