Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr 15;11:38.
doi: 10.1186/1741-7007-11-38.

Of Flies and Men: Insights on Organismal Metabolism From Fruit Flies

Free PMC article

Of Flies and Men: Insights on Organismal Metabolism From Fruit Flies

Akhila Rajan et al. BMC Biol. .
Free PMC article


The fruit fly Drosophila has contributed significantly to our general understanding of the basic principles of signaling, cell and developmental biology, and neurobiology. However, answers to questions pertaining to energy metabolism have been so far mostly addressed in more complex model organisms such as mice. We review in this article recent studies that show how the genetic tractability and simplicity of Drosophila are being used to identify novel regulatory mechanisms at the organismal level, and to query the co-ordination between energy metabolism and other processes such as neurodegeneration, circadian rhythms, immunity, and tumor biology.


Figure 1
Figure 1
Organs involved in metabolic homeostasis in Drosophila. Hormone names are in red, tissue names in blue, outputs in green. Figure adapted from Leopold and Perrimon [7].

Similar articles

See all similar articles

Cited by 32 articles

See all "Cited by" articles


    1. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006. Natl Health Stat Rep. 2009;13:1–8. - PubMed
    1. Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 1980;287:795–801. doi: 10.1038/287795a0. - DOI - PubMed
    1. Nickel W, Seedorf M. Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells. Annu Rev Cell Dev Biol. 2008;24:287–308. doi: 10.1146/annurev.cellbio.24.110707.175320. - DOI - PubMed
    1. Baker KD, Thummel CS. Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab. 2007;6:257–266. doi: 10.1016/j.cmet.2007.09.002. - DOI - PMC - PubMed
    1. Rajan A, Perrimon N. Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis. Dev Cell. 2011;21:29–31. doi: 10.1016/j.devcel.2011.06.034. - DOI - PMC - PubMed

LinkOut - more resources