Of flies and men: insights on organismal metabolism from fruit flies

BMC Biol. 2013 Apr 15;11:38. doi: 10.1186/1741-7007-11-38.


The fruit fly Drosophila has contributed significantly to our general understanding of the basic principles of signaling, cell and developmental biology, and neurobiology. However, answers to questions pertaining to energy metabolism have been so far mostly addressed in more complex model organisms such as mice. We review in this article recent studies that show how the genetic tractability and simplicity of Drosophila are being used to identify novel regulatory mechanisms at the organismal level, and to query the co-ordination between energy metabolism and other processes such as neurodegeneration, circadian rhythms, immunity, and tumor biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Drosophila melanogaster / metabolism*
  • Humans
  • Lipid Metabolism
  • Longevity
  • Mammals / metabolism
  • Stress, Physiological