Brugada syndrome after using cold medicine: is there any relation?

Rev Port Cardiol. 2013 May;32(5):415-7. doi: 10.1016/j.repc.2012.11.005. Epub 2013 Apr 12.
[Article in English, Portuguese]


Brugada syndrome (BrS) is associated with increased risk of ventricular arrhythmias and sudden death. Some drugs can trigger the electrocardiographic and arrhythmic manifestations of this syndrome. Cold medicines for symptom relief are sold without prescription in Brazil and most contain antihistamines and adrenergic agonists. We report a case of BrS probably triggered by the use of such medication.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brompheniramine / adverse effects*
  • Brugada Syndrome / chemically induced*
  • Histamine H1 Antagonists / adverse effects*
  • Humans
  • Male
  • Multi-Ingredient Cold, Flu, and Allergy Medications / adverse effects
  • Nasal Decongestants / adverse effects*
  • Phenylephrine / adverse effects*


  • Histamine H1 Antagonists
  • Multi-Ingredient Cold, Flu, and Allergy Medications
  • Nasal Decongestants
  • Phenylephrine
  • Brompheniramine