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Randomized Controlled Trial
. 2013 Aug;58:101-6.
doi: 10.1016/j.fct.2013.04.007. Epub 2013 Apr 13.

Effect of Korean Pear (Pyruspyrifolia Cv. Shingo) Juice on Hangover Severity Following Alcohol Consumption

Randomized Controlled Trial

Effect of Korean Pear (Pyruspyrifolia Cv. Shingo) Juice on Hangover Severity Following Alcohol Consumption

Ho-Sun Lee et al. Food Chem Toxicol. .


Korean pear has been used as a traditional prophylactic agent for alcohol hangover. However, its mechanism was not investigated in human yet. Therefore, we performed a randomized single blind crossover trial with 14 healthy young men to examine effects of Korean pear juice on alcohol hangover. All subjects consumed 540 ml of spirits (alcohol conc. 20.1 v/v%) after 30 min from the intervention, i.e. placebo or Korean pear juice treatment. Blood and urine specimens were collected in time-courses (9 time-points for 15 h after alcohol consumption). The total and average of hangover severity were alleviated to 16% and 21% by Korean pear juice at 15 h after the alcohol consumption, respectively (ps<0.05). Particularly, 'trouble concentrating' was significantly improved by the pear juice treatment (p<0.05). Impaired memory, and sensitivity to light and sound were significantly improved by Korean pear juice among the subjects with ALDH2*1/*1 or ALDH2*1/*2 genotypes (ps<0.05) but not in the subjects with ALDH2*2/*2 genotype. In addition, the pear juice treatment lowered levels of blood alcohol (p<0.01). Therefore, Korean pear juice may alleviate alcohol-hangover and its detoxification of alcohol seems to be modified by the genetic variation of ALDH2.

Keywords: ALDH2; AUC; Alcohol; Hangover; IRB; Korean pear; MDA; PCA; PK; Pharmacodynamics; Pharmacokinetic; Pharmacokinetics; RFLP; TBA; VHT; acetaldehyde dehydrogenase2; areas under the curve; institutional review board; malondialdehyde; perchloric acid; restriction fragment length polymorphism; thiobarbituric acid; vital sign and hematological tests.

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