Effect of supervised training on FEV1 in cystic fibrosis: a randomised controlled trial

J Cyst Fibros. 2013 Dec;12(6):714-20. doi: 10.1016/j.jcf.2013.03.003. Epub 2013 Apr 13.


Background: Long-term exercise interventions have been shown to improve vital capacity in cystic fibrosis (CF). Yet, no data are available indicating positive effects of long-term exercise training on FEV1.

Methods: 39 Swiss patients with CF were randomly divided into strength training (ST, n=12), endurance training (AT, n=17) and controls (CON(CH), n=10), and also compared with age-matched Swiss (n=35) and German (n=701) CF registry data. A partially supervised training of 3×30 min/week for 6 months took place with measurements at baseline and after 3, 6, 12 and 24 months. Primary outcome was FEV1 at 6 months.

Results: FEV1 increased significantly in both training groups compared with CON(CH) (AT:+5.8±0.95, ST:+7.4±2.5, CON(CH):-11.5±2.7% predicted, p<0.001) and both registry groups at 6 months. At 24 months, changes in favour of the training groups persisted marginally compared with CONCH, but not compared with registry data.

Conclusions: A partially supervised training over 6 months improved FEV1 but effects were basically gone 18 months off training. Regular long-term training should be promoted as essential part of treatment in CF.

Trial registration: ClinicalTrials.gov NCT00231686.

Keywords: AT; Aerobic training; CF; CON(CH); CON(D); Control group Germany; Control group Switzerland; Cystic fibrosis; Exercise capacity; FEV(1); FVC; Forced expiratory volume in one second; Forced vital capacity; Lung function; Maximal oxygen consumption at peak endurance; Maximal watt performance; Physical activity; Pulmonary rehabilitation; RV/TLC; Residual volume over total lung capacity; ST; Strength training; VO2(peak); VPA; Vigorous physical activity; W(max).

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cystic Fibrosis / physiopathology*
  • Cystic Fibrosis / therapy*
  • Exercise Therapy*
  • Female
  • Forced Expiratory Volume*
  • Humans
  • Male
  • Physical Endurance
  • Quality of Life
  • Resistance Training
  • Vital Capacity
  • Young Adult

Associated data

  • ClinicalTrials.gov/NCT00231686