Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium

Clin Pharmacol Ther. 2013 Jul;94(1):113-25. doi: 10.1038/clpt.2013.77. Epub 2013 Apr 10.


The International Transporter Consortium (ITC) organized a second workshop in March 2012 to expand on the themes developed during the inaugural ITC workshop held in 2008. The final session of the workshop provided perspectives from regulatory and industry-based scientists, with input from academic scientists, and focused primarily on the decision trees published from the first workshop. These decision trees have become a central part of subsequent regulatory drug-drug interaction (DDI) guidances issued over the past few years.

Publication types

  • Review

MeSH terms

  • Cooperative Behavior
  • Decision Trees*
  • Drug Discovery / methods*
  • Drug Interactions*
  • Humans
  • Membrane Transport Proteins / metabolism*
  • Pharmaceutical Preparations / metabolism*
  • Risk Assessment


  • Membrane Transport Proteins
  • Pharmaceutical Preparations