Pain‑relieving effect of a compound isolated from white peony root oral liquid on acute radiation‑induced esophagitis

Mol Med Rep. 2013 Jun;7(6):1950-4. doi: 10.3892/mmr.2013.1427. Epub 2013 Apr 11.


Acute radiation‑induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anesthetics, Local / pharmacology
  • Animals
  • Anti-Bacterial Agents / toxicity
  • Anti-Inflammatory Agents / pharmacology
  • Body Weight / drug effects
  • Body Weight / radiation effects
  • Dexamethasone / pharmacology
  • Disease Models, Animal
  • Esophagitis / drug therapy*
  • Esophagitis / etiology
  • Gentamicins / toxicity
  • Immunohistochemistry
  • Lidocaine / pharmacology
  • Male
  • Paeonia / chemistry*
  • Pain Management*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Roots / chemistry
  • Radiation Injuries / complications
  • Radiation Injuries / drug therapy*
  • Rats
  • Rats, Wistar
  • Substance P / metabolism
  • X-Rays


  • Anesthetics, Local
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Gentamicins
  • Plant Extracts
  • Substance P
  • Dexamethasone
  • Lidocaine