Long-term outcomes of pediatric ischemic stroke in adulthood

J Child Neurol. 2014 Jun;29(6):782-8. doi: 10.1177/0883073813484358. Epub 2013 Apr 15.


This population-based study assesses the long-term impact of childhood stroke on function and independence in young adults. We undertook a cross-sectional outcome study of patients with arterial ischemic stroke and cerebral sinovenous thrombosis, beyond 18 years of age. We studied 26 patients; 21 arterial stroke, 5 cerebral sinovenous thrombosis, with 16 females. Mean age at assessment was 21.5 years, and mean follow-up time was 10.8 years. According to the modified Rankin Scale, final outcomes were 37% normal, 42% mild, 8% moderate, and 15% severe deficits. Risk factors for abnormal functional outcome included arterial ischemic stroke, presence of arteriopathy, and 1-year poststroke Pediatric Stroke Outcome Measure score ≥ 2 (P < .05). Most (77-84%) were independent in driving, relationships, and employment. Functional status at 1 year poststroke strongly predicts long-term outcome. Mental illness in one-quarter of young adults surviving childhood stroke represents an important direction for research.

Keywords: outcome; outcome measures; stroke.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Ischemia / complications*
  • Community Health Planning
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Outcome Assessment, Health Care
  • Predictive Value of Tests
  • Statistics, Nonparametric
  • Stroke / diagnosis*
  • Stroke / etiology*
  • Young Adult