Targeted delivery of siRNA to differentiated murine myotubes in culture by a conjugate of cationic oligopeptide with FS2 venom

Biochemistry (Mosc). 2013 Apr;78(4):418-23. doi: 10.1134/S0006297913040111.


A conjugate of the ligand of FS2 venom dihydropyridine receptors with a cationic arginine-containing oligopeptide was synthesized. It was found that the conjugate provides siRNA delivery to murine myotubes differentiated in vitro. The effect of RNA interference with the use of siRNA complexes with the conjugate was observed when siRNA concentrations were an order of magnitude lower than those used in the case of siRNA complexes with a non-conjugated oligopeptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cations / chemistry
  • Cell Differentiation
  • Cells, Cultured
  • Drug Delivery Systems*
  • Ligands
  • Mice
  • Muscle Fibers, Skeletal / cytology
  • Muscle Fibers, Skeletal / metabolism*
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism
  • Peptides / chemistry*
  • Peptides / metabolism
  • RNA, Small Interfering / metabolism*
  • Snake Venoms


  • Cations
  • Ligands
  • Oligopeptides
  • Peptides
  • RNA, Small Interfering
  • Snake Venoms
  • toxin FS2