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, 44 (5), 565-73

Expression and Redistribution of β-Catenin in the Cardiac Myocytes of Left Ventricle of Spontaneously Hypertensive Rat

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Expression and Redistribution of β-Catenin in the Cardiac Myocytes of Left Ventricle of Spontaneously Hypertensive Rat

Qiaoli Zheng et al. J Mol Histol.

Abstract

Beta-catenin is not only an adhering junction protein, but also the central player of the canonical Wnt signalling pathway. In order to investigate the roles of β-catenin in the mechanism of myocardial hypertrophy, we determined the expression and distribution of β-catenin in the cardiomyocytes of spontaneously hypertensive heart failure (SHHF) rats and age-matched Wistar-Kyoto (WKY) rats. We identified the reducing of β-catenin expression in the membrane protein fraction but increasing in the nuclear protein in the 6 and 12 month-old SHHF rats as compared with the age-matched WKY rats by Western blotting. Immunolabeling of β-catenin colocalized with cadherin at the intercalated disc sites and showed nuclear accumulation in myocytes of SHHF rats. We also revealed that the association between glycogen synthase kinase-3β and β-catenin had weakened in the 6 month-old SHHF rats as compared with the age-matched WKY rats by immunoprecipitation. These findings suggested that nuclear translocation of β-catenin might play important roles in regulating signal transduction in the decompensated hypertrophy stage.

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References

    1. Biochem Biophys Res Commun. 2009 Dec 11;390(2):258-62 - PubMed
    1. J Mol Histol. 2013 Jun;44(3):357-67 - PubMed
    1. Cell. 1994 Dec 2;79(5):791-803 - PubMed
    1. Biotechniques. 1999 Feb;26(2):202-4, 206 - PubMed
    1. Hypertension. 2007 Mar;49(3):427-8 - PubMed

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